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Erschienen in: Wiener klinische Wochenschrift 7-8/2012

01.04.2012 | short report

Molecular epidemiology ofPseudomonas aeruginosa in cystic fibrosis patients from Southeast Austria

verfasst von: Lilian Masoud-Landgraf, Alexandra Badura, Ernst Eber, Gebhard Feierl, Josefa Posch, Gernot Zarfel, Maximilian Zach, Egon Marth

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2012

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Summary

Pseudomonas aeruginosa is the major pathogen in the cystic fibrosis (CF) lung, the predominant source of its acquisition, however, is under discussion. In order to study the molecular epidemiology, we evaluated 86 P. aeruginosa isolates from 43 CF patients from southeast Austria. The DiversiLab system was used to identify genetic relationships among the isolates. Antibiotic susceptibilities were tested with a broth microdilution method (Micronaut Merlin). A total of 39 unrelatedP. aeruginosa genotypes were found of which 34 were unique to a single patient and one was unique to a sibling pair. We found low rates of resistance for β-lactams with resistance to piperacillin/tazobactam and ceftazidime ranging from 4 to 6%. Resistance rates for meropenem and ciprofloxacin were 11% and 15%, respectively. The prevalence of multidrug-resistant isolates was 2%. We conclude that the majority ofP. aeruginosa isolates from CF patients originate from environmental sources and patient-to-patient spread is very uncommon in our centre.
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Metadaten
Titel
Molecular epidemiology ofPseudomonas aeruginosa in cystic fibrosis patients from Southeast Austria
verfasst von
Lilian Masoud-Landgraf
Alexandra Badura
Ernst Eber
Gebhard Feierl
Josefa Posch
Gernot Zarfel
Maximilian Zach
Egon Marth
Publikationsdatum
01.04.2012
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2012
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-012-0156-7

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